The Final Call
Free Play: Over 54.5 (-107) · Win
Final: Detroit Lions 31, Buffalo Bills 41.
NFL pick · Sep 17, 2026
Detroit Lions vs Buffalo Bills Prediction
Detroit Lions visit Buffalo Bills on Thursday, September 17, 2026 at 8:15 PM ET. Final Call Pro’s AI analyst reads this matchup and posts a Final Call only when the evidence is strong enough.
What the analyst reviews for NFL
- Quarterback and key personnel availability
- Offensive and defensive efficiency
- Rest, travel and schedule spot
- Home/away form
- Current moneyline, spread and total prices
Track record and method
Every published pick is locked before the game and graded on the final score, at the price posted when it locked, so performance can be judged on real results.
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